Recent Developments in Pharmaceutical Analysis
September 8-11, 2019
PLENARY LECTURERS
Gabriele Cruciani, Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia (Italy)
EPILIPIDOMICS IN PHARMACEUTICAL ANALYSIS
Gabriele Cruciani is full professor of Organic Chemistry and Cheminformatics at the University of Perugia, Italy. Prof. Cruciani is the scientific director of Molecular Discovery company based in London, and is the director of the human Cytochrome Consortium Initiative (a consortium of seven pharmaceutical companies collaborating to address metabolism issues in predictive human metabolism). Cruciani is also a member of the technical scientific advisory board of several pharmaceutical companies.In 2001 he got the Corvin Hansch Award from the Molecular Modeling Society in USA for his work on QSAR and Molecular Modeling, and in 2005 he got the Research Award from Società Chimica Italiana, Organic Chemistry Division, and in 2009 he was the recipient of the Novartis Research Award. In 2014 he was the recipient of the gold medal Angelo Mangini award from Italian Chemical Society and finally in 2015 he was the recipient of the gold medal Herman Wold Award from Swedish Chemical Society.. Prof. Cruciani made significant contributions to the field of ADME and computer-aided drug design, due to his over two decades of software production for data mining and drug discovery experience, focused on drug informatics, cheminformatics, small-molecule and target informatics, and virtual screening. He obtained several EU grants and Italian research grants, plus a number of support grants from pharmaceutical companies. Cruciani is included in the Top Italian Scientists list
Alfonsina d'Amato, Department of Pharmaceutical Sciences, University of Milan, Milan (Italy)
PROTEIN NETWORK ANALYSIS IN MEDICINAL CHEMISTRY
Dr. D’Amato is a senior researcher in analytical chemistry at the Department of Pharmaceutical Sciences of University of Milan. She received her PhD in chemical sciences at University of Salerno in 2005; she was post doc at San Raffaele Scientific Institute (MI) and at Politecnico di Milano. She was Research Associate in Clinical Proteomics at University of Manchester (UK). In 2014 she was recruited as permanent proteomics Senior Research Scientist at Quadram Institute Bioscience in Norwich, UK. She has expertise in the study of quantitative protein profiling of complex biological, pharmaceutical and food matrixes, using advanced high-resolution mass spectrometry in combination with chromatographic purifications. Her main research interest is the understanding of molecular mechanism of bioactive compounds, involved in the maintenance of health and prevention of disease, by protein network analyses. She is co-author of 46 peer reviewed papers and 3 book chapters. She has successful international and national collaborations, contributing to externally funded research programmes
Duncan Graham, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow (United Kingdom)
RAMAN AND SERS SPECTROSCOPY FOR BIOANALYSIS
Duncan Graham is the Research Professor of Chemistry and Head of Department for Pure and Applied Chemistry at the University of Strathclyde in Glasgow. He obtained his BSc Honours and PhD in Chemistry from the University of Edinburgh before joining the University of Strathclyde in 1996. In 1997 he secured a 5-year BBSRC Fellowship to start his independent research career. He was appointed as a lecturer in 2002 and promoted to professor in 2004 then elected to the fellowship of the Royal Society of Edinburgh (Scotland’s National Academy) in 2007. He was awarded the RSC’s Corday Morgan prize in 2009, a Royal Society Wolfson Merit Award in 2010, the Craver Award of the Coblentz Society, a Fellows Award from the Society of Applied Spectroscopy in 2012, the RSC’s Theophilus Redwood award in 2016 and the FACSS Charles Mann Award in 2017. He is Editor in Chief of the RSC journal Analyst and serves several editorial advisory boards including Chemical Society Reviews and Chemical Science. He is president of the analytical division of the Royal Society of Chemistry, and chair of the analytical chemistry trust fund. He has published over 250 papers with 16 patents and has supervised over 60 PhD students and 35 postdoctoral researchers. His scientific interests are in using synthetic chemistry to produce sensors that respond to a specific biological species or events as measured by Raman spectroscopy or SERS and collaborating with scientists from different disciplines to exploit these approaches
Jean Luc Wolfender, School of Pharmaceutical Sciences, University of Geneva, Geneva (Switzerland)
HOW FAR DEEP CAN WE DECIPHER THE COMPOSITION OF COMPLEX NATURAL EXTRACTS WITH ADVANCED GENERIC METABOLITE PROFILING METHODS?
Jean‐Luc Wolfender is a chemist, who completed a PhD in pharmacognosy with Prof. Kurt Hostettmann (University of Lausanne, Switzerland, 1993). After being responsible of the analytical services of this laboratory, he performed his postdoc with Prof. Al Burlingame on Conus venom profiling (UCSF, San Francisco). He is now full Professor at the Phytochemistry and Bioactive Natural Product research unit of the School of Pharmaceutical Sciences of the University of Geneva (Switzerland), where he was the president of the School and is presently vice-dean of the Faculty of Sciences. He has been strongly involved in the 90s in the introduction of LC‐MS and LC‐ NMR for the profiling of crude plants extracts for dereplication purposes in natural product based drug discovery research programs. He is currently developing innovative MS‐ and NMR‐ based metabolomics strategies in the frame of projects related to phytochemistry, microbial interactions and phytotherapy. He is specialised in the de novo structure identification of biomarkers at the microgram scale and is using a miniaturised approach that combines activity‐based HPLC profiling and high content information bioassays such as those involving zebrafish. His main research interests are focused on the search of novel inducible bioactive natural products in response to various biotic and abiotic stimuli as well for the study of the mode of action of phytopharmaceuticals from a systems biology perspective. He has many collaborations with South America and Asia mainly in relation with bioactivity guided isolation studies for the discovery of novel natural products of therapeutic interest and his involved in the organisation of workshops for the promoting metabolomics with the natural product community
KEYNOTE SPEAKERS
Anna Rita Bilia, Department of Chemistry “Ugo Schiff”, University of Florence, Florence (Italy)
DNA BARCODING, NIR, AND SENSORS AS ALTERNATIVE/INTEGRATIVE ANALYTICAL TOOLS FOR QUALITY OF NATURAL PRODUCTS
Prof. Dr. Anna Rita Bilia is associate professor at the University of Florence. She is Director of the Post-graduate School of Hospital Pharmacy. In 1995 she got the national award "Claudio Redaelli" for outstanding young researchers in the field of phytochemistry and in 2002 she got the international "Egon Stahl Medal" for researchers younger than 40 years, working in natural products. In 2018 she got the Qihuang International Prize from the China Association of Chinese Medicine for her outstanding achievements in the field of analysis and innovative formulations of extracts and natural products from Chinese medicine.She is leading the group of natural products analysis and pharmaceutical technology at the Department of Chemistry. She is the president of Interdepartmental Center of Services for Biotechnologies of Agrarian, Chemical, Industrial interest (CIBIACI).She is expert of the European Pharmacopoeia and member of the TCM group. She is president of the International Society for Medicinal Plant and Natural Product Research (GA). She is the Italian delegate of the board of directors and member of the scientific committee of the European Scientific Cooperation on Phytotherapy (ESCOP). She is former president of the Italian Society of Phytochemistry and Sciences of Plants for Medicinal, Food and Cosmetic use (SIF). Prof. Bilia’s list of publications shows more than 250 papers in the most reputed international journals of her field of research, she is authors of numerous invited book monographs and chapters
Franca Cattani, Analytical Development Department, Dompè Biotech, L’Aquila (Italy)
NEW INSIGHT IN THE ANALYTICAL DEVELOPMENT LEADING TO MARKETING AUTHORIZATION OF BIOTECHNOLOGICAL PRODUCTS: A CASE STUDY
Franca Cattani is a Biologist with a PhD in the Biomedical Sciences and a Specialization in Clinical Pathology obtained at L’Aquila University. She joined Dompé farmaceutici S.p.A. on 2002 as researcher in the Preclinical Pharmacology Department. In the 2006 received a price by the Italian Society of Pharmacology as “best young researcher” based on a published work on contact hypersensitivity. From 2009 onward, she was part of the Dompé Biotech Analytical Development as researcher and today as Manager.She is involved in biotechnological product analysis and characterization as well as on method development and validation covering biological, biochemical and chemical physical techniques. In this context, her contribution is focused on both Drug Substances and Drug Products and is aimed to set up adequate analytical panels to obtain orthogonal information leading to a robust assessment of the product quality.With her analytical group, she also performs studies on chemical entities and bioanalytical assays on samples collected during non-clinical and clinical trials for pharmacokinetics, toxicokinetics, bioequivalence and biodistribution evaluations. In the last three years, she actively contributed to the interactions with the regulatory authorities like EMA and FDA for the successful achievement of the marketing authorization of a biotechnological orphan drug for an ophthalmological rare disease.
Bezhan Chankvetadze, Institute of Physical and Analytical Chemistry, Tbilisi State University, Tbilisi (Georgia)
NEW DEVELOPMENTS IN SEPARATION OF ENANTIOMERS OF CHIRAL DRUGS WITH POLYSACCHARIDE-BASED CHIRAL STATIONARY PHASES
Bezhan Chankvetadze is Full Professor for Physical Chemistry and director of the Institute of Physical and Analytical Chemistry at the Tbilisi State University in Tbilisi, Georgia. B. Chankvetadze has published over 200 research papers in peer reviewed journals, over 30 review papers and book chapters and holds several patents of the former Soviet Union, USA, Germany and Japan. B. Chankvetadze has published one monograph (Capillary Electrophoresis in Chiral Analysis, Wiley&Sons, Chichester, UK, 1997) and edited one multiautored book (Chiral Separations, Elsevier Science, 2001). He has edited and co-edited many special issues of the journals J. Chromatogr. A, Electrophoresis, J. Pharm. Biomed. Anal., and Journal Separation Science. B. Chankvetadze has given over 250 presentations on the international conferences. He is the Editor of the Journal of Pharmaceutical and Biomedical Analysis and a member of the editorial boards of Journal of Chromatography A, Electrophoresis, Journal of Separation Science, Chirality, Acta Chromatografica and several other journals. B. Chankvetadze is the recipient of “Journal of Chromatography Top Cited Article Awards” in 2005, 2006 and 2010, the recipient of “2006 Belgian Society of Pharmaceutical Science Award of Recognition”, “The Scientist of the Year 2016” award of the Rustaveli National Science Foundation (Georgia), and the joint Csaba Horvath Memorial Award of the Hungarian Separation Science Society and Connecticut Separation Science Council, USA (2017). Prof. B. Chankvetadze is Full Member of the Georgian National Academy of Sciences
Sebastiaan Eeltink, Department of Chemichal Engineering, Vrije University of Brussels (Belgium)
TOWARDS ULTRA-HIGH PERFORMANCE SEPARATIONS USING SPATIAL THREE-DIMENSIONAL LIQUID CHROMATOGRAPHY
Sebastiaan Eeltink received his PhD degree in Analytical Chemistry in 2005 from the University of Amsterdam, The Netherlands for his dissertation “Packed and monolithic capillary columns for LC”. From 2005-2007, he conducted post-doctoral research in the Svec/Fréchet group at the University of California, Berkeley, USA and he was a guest scientist at The Molecular Foundry in the Lawrence Berkeley National Laboratory. Here, he developed novel column formats, including coated capillary columns and monolithic structures in microfluidic chips. In 2007 he joined Dionex (currently Thermo Fisher Scientific) and conducted research on packed and monolith capillary columns for bioanalysis.In 2009, Sebastiaan received an Odysseus Award from the Research Foundation Flanders to establish his research group at the Vrije Universiteit Brussel. He is now full professor leading a research team focusing on development and characterization of novel column structures for liquid chromatography, design of novel microfluidic chip solutions for multi-dimensional separations, and advancement of LC-MS workflows to characterize contemporary biopharmaceutical and life-science mixtures. He is author of more than 95 scientific publications, 3 book chapters, and 3 patent applications on spatial three-dimensional liquid chromatography
Massimo Dondio, Aphad S.r.l, Milano (Italy)
7-HYDROXYMATAIRESINOL: A PK/PD CASE STUDY IN A RODENT MODEL OF PARKINSON’S DISEASE
G. Massimo Dondio got his Industrial Chemistry Degree at the University of Milan in 1986. From 1998 he worked for SmithKline Beecham (SB) Italy as Medicinal Chemist and Senior Team Leader of the Delta Opioid Agonists Programme. In 1999 he was appointed Assistant Director Medicinal Chemistry Italy. In 2001 together with other R&D Managers of SB he founded the spin-off named NiKem Research a CRO involved in integrated medicinal chemistry services and was appointed as Director of DMPK and Developability Sciences. Presently is Chief Operating Officer and co-founder of Aphad Srl a CRO for preclinical and clinical pharmacokinetics analytical services. He is the author of more than 40 articles on international journals and of 17 published patent applications. He presented his Medicinal Chemistry and DMPK works at several national and international conferences and he held lectures at several Universities (University of Siena, Pavia, Genova, Pavia, Pisa and Milano)
Szabolcs Fekete, School of Pharmaceutical Sciences, University of Geneva, Geneva (Switzerland)
LIQUID CHROMATOGRAPHIC ANALYSIS OF BIOPHARMACEUTICALS: CURRENT AND FUTURE POSSIBILITIES
Szabolcs Fekete holds a PhD degree in analytical chemistry from the Technical University of Budapest, Hungary. He worked at the Chemical Works of Gedeon Richter Plc at the analytical R&D department for 10 years. Since 2011, he is working at the University of Geneva in Switzerland in the group of Analytical Pharmaceutical Chemistry. He contributed ~130 journal articles, authored book chapters and edited handbooks. His main interests include liquid chromatography (RP, IEX, SEC, HIC, SFC, HILIC), column technology, mass transfer processes, method development, pharmaceutical and protein analysis
Michael Lämmerhofer, Pharmazeutisches Institut, Eberhard-Karls-University of Tübingen, Tübingen (Germany)
LIPIDOMICS PROFILING: A WINDOW OF OPPORTUNITY IN CLINICAL ANALYSIS
Michael Lämmerhofer is Full Professor (W3) for Pharmaceutical (Bio-)Analysis at the University of Tübingen, Germany (since 2011). He graduated in Pharmaceutical Sciences in 1992 and earned his PhD in Pharmaceutical Chemistry in 1996 at the University of Graz, Austria (Supervisor: Prof. Wolfgang Lindner). Between 1997 and 2001 he was assistant professor and since 2002 associate professor at the University of Vienna, Department of Analytical Chemistry. From 1999-2000 he spent a year of research as post-doc at the Department of Chemistry of the University of California, Berkeley. Since 2007, he is associate editor of Journal of Separation Science. His research interests include the development of functionalized separation materials (chiral stationary phases, mixed-mode phases, chemo- & bioaffinity materials, nanoparticles, monoliths), metabolomics and lipidomics, pharmaceutical analysis (impurity profiling, enantioselective analytics) and biopharmaceuticals analysis (peptides, oligos, proteins, plasmids)
Gertrud E. Morlock, Institute of Nutritional Science, Justus-Liebig-Universität Gießen, Gießen (Germany)
THE COMPLEXITY OF BOTANICALS, FOOD AND OF THE GLOBAL PRODUCT CHAIN - ARE WE ANALYTICALLY ON THE RIGHT TRACK?
Gertrud Morlock is full professor (W3) and Chair of Food Science at the Justus Liebig University Giessen in Germany since 2012 (www.uni-giessen.de/food). Also, she is the Director of the TransMIT center of Effect-Directed Analysis in Giessen. She is experienced in miniaturized planar chromatography (office chromatography), hyphenations with MS, open-source systems, pattern recognition techniques, effect-directed analysis, bioprofiling, analysis of food, botanicals, cosmetics, commodities, pharmaceutical formulations, environmental samples, trace analysis etc. She graduated PhD under supervision of Professor Jork and Professor Engelhardt at the Faculty of Chemistry, University of Saarland. She has experience and worked in international industry for years, and went back to academia in 2004. In 2008, she made her professorial thesis at the University of Hohenheim in Stuttgart. In 2010, she became apl. Professor at the Institute of Food Chemistry at Professor Schwack. In 2009, she was awarded with the Kurt-Täufel-Preis des Jungen Wissenschaftlers (Young Researcher Award) of the German Society of Food Chemistry, in 2010 with the Highly Cited Author Award of the Journal of Chromatography A, and in 2018 with the Father of Stevia Award to mention few. She has made over 130 peer-reviewed original research paper since 2006, over 70 further scientific papers and book chapters, is editor of the CBS journal and the online database CCBS containing ca. 11000 abstracts on TLC/HPTLC, conducted over 70 workshops, made over 240 posters and 260 oral presentations at symposia. She is currently active in several scientific committees, boards and expert groups